ABSTRACT
"At present, majority of the small molecular drugs used in clinics target proteins, they exert the efficacy through the binding to specific sites on the target protein. However, the ""druggable"" protein targets account for a small portion of the total number of proteins, and ""non-druggable"" proteins account for 80%, because of not having suitable drug binding sites. In the central rule, RNA is located in the upstream of proteins and controls the transcription of proteins. The research of small molecule drugs targeting RNA can solve the problem of protein ""undruggable proteins"" in some extent. This review summarizes the representative research achievements of small molecular drugs targeting RNA in recent years, and the screening methods applied to this field, with the focuses on the latest progress of small molecular drugs targeting novel coronavirus RNA. © 2022, Chinese Pharmaceutical Association. All rights reserved."
ABSTRACT
OBJECTIVE: To explore the novel models of internet-based pharmacy services during the period of coronavirus disease 2019 (COVID-19). METHODS: The process specification, management system, qualification and quality control were discussed and astablished. Retrieving 2-month of internet pharmacy counseling records, and conducting statistical analysis on the relevant information, which includes the counseling content, drug types, numbers, cases and patient evaluation survey. RESULTS: This new model built an internet pharmacy counseling platform in Peking Union Medical College Hospital (PUMCH) on March 2020. Relevant systems and standardized processes has be established. After the implementation of the internet-specific pharmacy counseling service, a total of 615 qualified counseling records were collected by April 12, 2020. The number of online pharmacists, the numbers of counseling, daily pharmacist visits have increased continuously. CONCLUSION: In conclusion, the implementation of internet pharmacy counseling services during the period of coronavirus disease 2019 (COVID-19) solves the drug-related demands from patients as well as reduces the potential risk of cross-infections among patients. This model contributes to the establishment of a series of new pharmacy services to fight against the COVID-19. In addition, it also plays an important role in helping specialist pharmacists provide convenient, patient-centered pharmacy services.